No studies have evaluated the effects of 4 years of treatment with raloxifene; any extrapolation beyond 4 years is not strictly evidence-based. Given that caveat, with respect to osteoporosis. Doctors give trusted answers on uses, effects, side-effects, and cautions: Dr. Roth on evista side effects long term: none -- but your body may develop tolerance. Long-term safety and efficacy of raloxifene in the prevention and treatment of postmenopausal osteoporosis: an update Enrico M Messalli and Cono Scaffa Department of Gynaecology, Obstetrics and Reproductive Medicine, Second University of Naples, Largo Madonna delle Grazie 1, Naples, Italy Our Evista (raloxifene hydrochloride) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication. This is not a complete list of side effects and others may occur. Side Effects. Drug information provided by: IBM Micromedex. Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. How to use Evista. Read the Medication Guide provided by your pharmacist before you start taking raloxifene and each time you get a refill. If you have any questions, ask your doctor or pharmacist. How to take raloxifene. Before you start the treatment, read the manufacturer's printed information leaflet from inside the pack. It will give you more information about raloxifene and will provide you with a full list of the side-effects which you may experience from taking it. Commonly reported side effects of raloxifene include: infection, flu-like symptoms, hot flash, and sinusitis. Other side effects include: lower limb cramp. See below for a comprehensive list of adverse effects. It's not that I don't trust doctors, but they rely on information supplied by drug companies who are out to make a profit. And the long-term effects of some of the drugs used for treatment aren't even known yet. Along with its needed effects, raloxifene (the active ingredient contained in Evista) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.